ESPCI web site
ESPCI Paris - PSL
ESPCI Paris - PSL is a major institution of higher education (a French "Grande Écoled’ingénieurs"), an internationally renowned research center (6 Nobel Prizes), and a fertile ground of innovation for industry (3 start-ups created/year). ESPCI is a highly multidisciplinary environment with teaching and research in physics, chemistry and biology.
Philippe Nghe team
A central question in the origin of life is how evolution could have emerged in physical-chemical systems. RNA is an experimental model for the prebiotic world because RNA is both an information carrier and a catalyst. RNAs derived from group I introns have been shown to self-reproduce from smaller fragments, recombine other RNAs, and produce novel ribozymes. Therefore, RNA is a highly promising model to build an artificial reactions networks capable of evolution. However, a system made of RNA and capable of evolution remains to be discovered.
The project aims to build in vitro RNA reaction networks integrating recombination and template-based ligation as the fundamental driving forces of evolution. The challenge is to implement Darwinian properties of variation, reproduction with heredity and selection, and combine them, with the ambition to discover paths for the gradual emergence of evolution. We will use a combination of directed evolution, rational design of reaction networks, sequencing and microfluidics, in close collaboration with theory.
Requirements
We are seeking a highly motivated experiencedengineer to work on molecular biology and RNA biochemistry of RNAand next generation sequencing.Flexibility, autonomy, the ability to work in a highly multidisciplinary team and good interpersonal skills are essential.
Recruitment terms}
:
Starting date : as soon as possible
Duration : 24 months
Salary : according to professional experience
Address your applications(CV + cover letter) by email to :
Dr.Philippe NGHE
ESPCI Paris–LBC Team
10 Rue Vauquelin
75005 Parisjob-lbc@espci.fr