ESPCI web site
We are looking for a talented scientist who wants to join an interdisciplinary team developing a new microfluidic-based drug screening technology, with the aim to create a spin-off company. As a postdoctoral researcher, you will develop and validate a 3D hydrogel-based lung cancer model in an innovative microfluidic device.
Project background :
We aim to develop the first platform for high-throughput combinatorial drug screening on 3D cell models. This platform combines state-of-the-art microfluidics, cell biology, image analysis, and bioinformatics. Leveraging the power of microfluidic technology and translating high-quality data sets into relevant therapeutics solutions, we aim to become a European leader in drug combination therapies with a broad range of applications : drug discovery, drug repurposing/boosting, and personalized medicine. We benefit from the financial and technical support of public and private institutions : Sanofi, PSL University, ESPCI Paris, and BPI France.
The team :
ESPCI Paris-PSL is a major institution of higher education (a French "Grande École d’ingénieurs"), an internationally renowned research center (6 Nobel Prizes), and a fertile ground of innovation for industry (3 start-ups created/year). ESPCI is a highly multidisciplinary environment with teaching and research in physics, chemistry, and biology.
The Biophysics and Evolution Laboratory, located in the center of Paris at IPGG institute, is directed by Dr. Philippe NGHE. The research activities are based on experimental evolution, molecular biology, screening technologies, quantitative analysis, and modeling. Dr. NGHE is awarded a Human Frontier Science Program grant and the European Research Council. On a day-to-day basis, you will work closely with Reza KOWSARI, who developed and patented this technology during his PhD.
Your main missions :
• Prepare and validate a 3D model for lung cancer in natural and synthetic hydrogels
• Adapt the cell model to our microfluidic platform
• Perform drug sensitivity within and without microfluidic devices
• Qualitative and quantitative analysis of cell growth
• Develop laboratory methods and protocols
• Work according to project schedules and report on progress internally
• Work closely with an interdisciplinary team of engineers, biologists, and business developers
Your profile :
• MSc or PhD in Biology or related fields with a focus on in vitro tumor models
• Extensive experience in 3D cell culture, cell characterization, and assay development
• Extensive experience in fluorescence and confocal microscopy
• A previous experience with microfluidics would be highly appreciated
• A previous experience with bioimage analysis would be highly appreciated
• The desire to contribute to a collective entrepreneurial project in a highly dynamic team
• Ability to work independently and with a problem-solving mindset
• Fluency in English and excellent communication skills
Terms and Conditions :
You will be recruited by the ESPCI on an 18-month renewable contract. You will have the possibility to join the start-up company which is planned to be created in 2023 as one of the first employee. Compensation package will be competitive, depending on your experience.
Contact and Candidature :
We look forward to receiving your CV by contacting Dr. Philippe NGHE (philippe.nghe@espci.fr) or Reza KOWSARI (reza.kowsari@espci.fr). Review of applications will begin on October 1st, 2022, with the position to start as soon as filled (negotiable).